Project Description: to Evaluate the Safety, Tolerability and Immunogenicity of a Radiation-attenuated Plasmodium falciparum (Pf) Sporozoite Vaccine (PfSPZ Vaccine) in Equatoguinean Adults, Children and Infants, and Comparison with Non-attenuated Pf Sporozoites (PfSPZ Challenge) Administered under Chloroquine Prophylaxis (PfSPZ-CVac Approach) for Efficacy against Controlled Human Malaria Infection (CHMI) to Evaluate the Safety, Tolerability and Immunogenicity of a Radiation-attenuated Plasmodium falciparum (Pf) Sporozoite Vaccine (PfSPZ Vaccine) in Equatoguinean Adults, Children and Infants, and Comparison with Non-attenuated Pf Sporozoites (PfSPZ Challenge) Administered under Chloroquine Prophylaxis (PfSPZ-CVac Approach) for Efficacy against Controlled Human Malaria Infection (CHMI)
Principal Investigator : Salim Abdulla
Department Name : EHES
Time frame: (2013-06-01) - (2021-12-31)